Sly: check out a company called Yamicsoft. I've been using their products for years for every major version of windows. It's intuitive, very straightforward, lets you clean up your registry, even defrag it, finds orphaned entries, orphaned dll's, and all sorts of stuff that can degrade system performance. it also centralizes a lot of the Windows tools that let you toggle them on and off that may cause a performance hit.
Optimize Windows, Tweak Windows, Repair Windows, Clean Windows, Speed Up Windows - Yamicsoft
Don't let the simplistic looking website or product screenshots give you the wrong impression. This product is very good and well worth the money.