The Republican Party isn't going to nominate a guaranteed loser. Trump is a caricature. Cruz is Tea Party. Paul is too Libertarian.
My guess would be Jeb Bush, but even he leans a little too left for the majority of the party. However, he probably has the best chances in a Presidential race just for that reason.
The Democratic Party has all but officially nominated Clinton. Sanders is gaining fast and has a very good shot at the nomination if Clinton can't clean up her image quick. As current VP, Biden isn't going to pull any votes from the right, which is an issue for him.
Of course, this is all just my opinion, but my guess for the Presidential race would have to be Jeb Bush vs Hillary Clinton. That guess only slightly outweighs my second guess of Jeb Bush vs Bernie Sanders.
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