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I don't do a lot of mailing now but I was a god in the late 90s. I've done some mailing stuff with Node with mongodb and async to manage queues. It's all concise and nonblocking so it's efficient as all get out.
With node there's a billion modules you can make use of. Like spintax, building messages off data, all that.
What kind of SMTP/hosting you use is important depending on how much volume you're getting. You can do custom mail methods too. I actually wrote a mailing module that takes a huge text file of webmail login credentials and it will resolve the SMTP server on the fly, all kinds of stuff.
Like I said I'm not doing huge mailings anymore. Back in the day I was pushing millions daily. What I like to do these days is seed with protonmail addresses and check the spamassassin report metrics in the headers. You can pretty easily see what specific problems you've got to work around.
If you want to set up one site and have me build a campaign script to your specs I'd do it for free. I don't run sites at all, just more focused on big data type stuff. I do have boatloads of data to share and map/reduce campaigns with. Like billions of records of all different sorts.
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